Clotrimazole (Clotic) is a prescription medication indicated for the treatment of fungal infections of the external auditory canal (otomycosis) in adult patients. Proper use of the medication, combined with a healthy lifestyle, helps improve treatment outcomes and reduce adverse reactions.

I. Detailed Dosage and Administration

1. Indicated Population and Treatment Duration

(1) Clotrimazole is indicated for patients 18 years of age and older with fungal infections of the external auditory canal caused by Aspergillus or Candida species.

(2) The treatment course is 14 consecutive days, administered twice daily (morning and evening), with approximately 12 hours between doses.

2. Specific Administration Instructions

(1) Before each use, warm the single‑dose bottle in your hand for 1 to 2 minutes to prevent dizziness caused by instilling cold liquid into the ear.

(2) Administer while lying on your side with the affected ear upward. Gently pull the auricle upward and outward. Instill the entire contents of the bottle and maintain this position for 1 minute to ensure adequate penetration into the ear canal.

II. Precautions for Use

1. Contraindications and Cautions

(1) Contraindicated in patients with a known hypersensitivity to clotrimazole.

(2) This product is only for use in patients with an intact tympanic membrane; use is not recommended in patients with tympanic membrane perforation.

(3) The safety profile in children, pregnant women, and lactating women has not been established. Consult a physician before use.

2. Potential Adverse Reactions

(1) Common adverse reactions include headache, application site pain, tinnitus, tympanic membrane perforation, and paresthesia.

(2) In the event of severe discomfort or suspected adverse reactions, contact a healthcare provider promptly or report to the relevant drug regulatory authority.

3. Storage and Handling Instructions

(1) Store at 20°C to 25°C. Keep unused bottles in their aluminum foil pouch to protect from moisture.

(2) Any unused bottles 30 days after the initial opening of the pouch should be discarded. Each bottle is for single use only; discard immediately after administration. Do not reuse.

III. Healthy Lifestyle Recommendations for Patients

1. Maintain Ear Cleanliness and Dryness

(1) Gently dry the external ear after bathing or swimming to prevent water retention.

(2) Clean the external ear only with a soft towel or tissue. Do not use cotton swabs or other objects to insert into the ear canal, as this may cause injury or introduce pathogens.

2. Avoid Predisposing Factors

(1) Minimize prolonged use of headphones or earplugs to maintain ear canal ventilation.

(2) Consider using earplugs for protection in dusty or humid environments, and clean them regularly.

3. Boost Immunity

(1) Maintain a balanced diet, regular exercise, and adequate sleep to enhance the body’s resistance and prevent fungal infection recurrence.

(2) For patients with chronic conditions such as diabetes, actively manage and control underlying diseases.

4. Complete Treatment as Prescribed

(1) Complete the full 14‑day course even if symptoms improve early to prevent infection recurrence or drug resistance.

(2) Seek prompt medical follow‑up if symptoms such as ear redness, increased pain, or purulent discharge occur during treatment.