Dasatinib (Sprycel) is a multi-targeted inhibitor against tyrosine kinases, which exerts anti-cancer effects by blocking multiple key tumor signaling pathways. With its unique "dual mechanism", it can not only act on the active conformation of ABL kinase but also bind to the inactive conformation, thereby effectively overcoming a variety of imatinib-resistant mutations.

Indications for Dasatinib (Sprycel)

Indications for Adult Patients

Newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic phase.

Patients with chronic phase, accelerated phase, or blast phase (myeloid or lymphoid) CML who are resistant or intolerant to previous treatments (including imatinib).

Patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) who are resistant or intolerant to previous treatments.

Indications for Pediatric Patients (Children Aged 1 Year and Older)

Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic phase.

Newly diagnosed Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL), which needs to be used in combination with chemotherapy.

Specifications and Properties of Dasatinib (Sprycel)

Appearance Characteristics

All tablets are white to off-white, biconvex, film-coated tablets.

20 mg: Round tablets, engraved with "BMS" on one side and "527" on the other side.

50 mg: Oval tablets, engraved with "BMS" on one side and "528" on the other side.

100 mg: Oval tablets, engraved with "BMS100" on one side and "852" on the other side.

The tablet core contains the active ingredient dasatinib, and the outer layer is coated with a film to reduce the risk of exposure for healthcare workers.

Storage Conditions for Dasatinib (Sprycel)

General Storage Requirements

Storage temperature: 20°C to 25°C (68°F to 77°F).

Short-term storage in an environment of 15°C to 30°C (59°F to 86°F) is permitted.

Precautions for Special Operations

Prohibition of crushing operations: Tablets must not be crushed, split, or chewed; they must be swallowed whole.

Safety Protection Measures

Latex or nitrile gloves must be worn when handling crushed tablets.

Pregnant individuals should avoid contact with broken tablets.

Special disposal procedures must be followed when discarding expired medications.