Azithromycin Tablets are macrolide antibacterial agents, widely used for the treatment of mild to moderate infections caused by specific susceptible bacteria. To use azithromycin appropriately, strict adherence to its indications, individualized dosing, and medication principles for special populations is required—this helps ensure therapeutic efficacy and reduce the risk of drug resistance.

How to Use Azithromycin Tablets

Adult Dosage

Community-acquired pneumonia/pharyngitis/skin infections: A single oral dose of 500 mg on Day 1, followed by 250 mg once daily from Day 2 to Day 5.

Acute bacterial sinusitis: 500 mg orally once daily for 3 consecutive days.

Genital ulcers and non-gonococcal infections: A single oral dose of 1 g; for gonococcal infections, a single oral dose of 2 g is required.

Acute exacerbation of chronic bronchitis: Two regimens are optional: (1) 500 mg orally once daily for 3 consecutive days; (2) 500 mg on Day 1, followed by 250 mg once daily from Day 2 to Day 5.

Pediatric Dosage

Acute otitis media: Three regimens are optional: (1) A single oral dose of 30 mg/kg; (2) 10 mg/kg orally once daily for 3 consecutive days; (3) 10 mg/kg on Day 1, followed by 5 mg/kg once daily from Day 2 to Day 5.

Pharyngitis/tonsillitis: 12 mg/kg orally once daily for 5 consecutive days.

Precautions for Administration

Both tablets and oral suspension can be taken on an empty stomach or after meals.

The oral suspension must be shaken well before use, and the reconstituted suspension should be used up within 10 days.

Dosage Adjustment for Azithromycin Tablets

Patients with Hepatic Impairment

Contraindications: Use is contraindicated in patients with a history of azithromycin-associated cholestatic jaundice/hepatic insufficiency.

If symptoms of hepatitis (e.g., jaundice, darkening of urine, fatigue) occur during medication use, discontinue the drug immediately and seek medical attention.

Medication Use in Special Populations for Azithromycin Tablets

Elderly Patients

Elderly patients are more prone to QT interval prolongation and torsades de pointes. Cardiovascular risk assessment is required before initiating medication.

Pregnant and Lactating Women

Pregnant women: Available data do not indicate a risk of major birth defects, but the benefits and risks must be weighed.

Lactating women: Azithromycin can pass into breast milk. It is recommended to monitor infants for the occurrence of diarrhea, vomiting, or rash during the mother’s medication period.

Patients with Underlying Diseases

Patients with cardiomyopathy: Use is contraindicated or should be used with caution, as it may increase the risk of arrhythmias.

Patients with myasthenia gravis: May exacerbate myasthenic symptoms; use with caution is required.